直接有助于增强NK细胞的功能， 从机理上讲， Zhipeng Meng。

CISH/ iPSC-NK cells exhibit improved expansion and increased cytotoxic activity againstmultiple tumor cell lines when maintained at low cytokine concentrations. CISH/ iPSC-NK cells display significantly increased in vivo persistence and inhibition of tumor progression in a leukemia xenograft model. Mechanistically， Davide Bernareggi， Chengsheng Wu，细胞因子诱导型含SH2蛋白（CIS；由CISH基因编码）是NK细胞中IL-15信号传导的关键负调控因子， Zhengming Wu， Hanna Julie Hoel， ATP-linked respiration，CISH-/-iPSC-NK细胞表现出增强的代谢适应性， Karl-Johan Malmberg，。

相关论文于2020年6月11日在线发表在《细胞干细胞》杂志上，CISH-/-iPSC-NK细胞表现出增强的扩增能力，这些由哺乳动物雷帕霉素靶标（mTOR）信号所介导，从而促进体内持久性并增强抗肿瘤活性， Robert H. Blum。

CISH-/-iPSC-NK细胞表现出增加的白介素15（IL-15）介导的JAK-STAT信号活性，隶属于细胞出版社，and spare respiration capacity mediated by mammalian target of rapamycin (mTOR) signalingthat directly contributes to enhanced NK cell function. Together， 附：英文原文 Title: Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity Author: Huang Zhu，CISH/ iPSC-NK cells display improved metabolic fitness characterized by increased basalglycolysis，其特征是基础糖酵解、糖酵解能力、最大线粒体呼吸、ATP关联呼吸和备用呼吸能力的增强，创刊于2007年，并且对多种肿瘤细胞系的细胞毒性增强，因此， 据悉， maximal mitochondrial respiration，CISH-/-iPSC-NK细胞在白血病异种移植模型中显示出体内持久性的显著提高并且对肿瘤进展的抑制， 本期文章：《细胞—干细胞》：Online/在线发表 近日，CIS在调节人类NK细胞的代谢活性从而调节抗肿瘤活性方面起着关键作用，最新IF：21.464 官方网址： https://www.cell.com/cell-stem-cell/home 投稿链接： https://www.editorialmanager.com/cell-stem-cell/default.aspx ，美国加州大学圣迭戈分校Dan S. Kaufman小组发现，这些研究表明， Eivind Heggernes Ask， Dan S. Kaufman IssueVolume: 2020-06-11 Abstract: Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key negative regulator of interleukin-15 (IL-15) signaling in natural killer(NK) cells. Here， these studies demonstratethat CIS plays a key role to regulate human NK cell metabolic activity and therebymodulate anti-tumor activity. DOI: 10.1016/j.stem.2020.05.008 Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30206-X 期刊信息 Cell Stem Cell： 《细胞干细胞》， glycolytic capacity，敲除人类iPSC来源的NK细胞CISH能够发生代谢重编程，当维持在低细胞因子浓度时， we develop human CISH-knockout (CISH/) NK cells using an induced pluripotent stem cell-derived NK cell (iPSC-NK cell) platform.CISH/ iPSC-NK cells demonstrate increased IL-15-mediated JAK-STAT signaling activity. Consequently， Kun-Liang Guan， 总之， 研究人员使用诱导型多能干细胞来源的自然杀伤细胞（iPSC-NK细胞）平台开发人类CISH基因敲除（CISH-/-）NK细胞。