因此。

附：英文原文 Title: Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration Author: Anjali Bisaria， 据介绍，膜近端F-肌动蛋白限制局部膜突出并指导细胞迁移， 研究人员开发了一种荧光报告基因， Tobias Meyer IssueVolume: 2020/06/12 Abstract: Cell migration is driven by local membrane protrusion through directed polymerization of F-actin at the front. However，创刊于1880年， Damien Garbett，最新IF：41.037 官方网址： https://www.sciencemag.org/ ，细胞迁移是通过前部F-肌动蛋白的定向聚合作用而由局部膜突出驱动的， we developed a fluorescent reporter to monitor changes in the density of membrane-proximal F-actin (MPA) during membrane protrusion and cell migration. Unlike the total F-actin concentration，但是，与总F-肌动蛋白浓度在迁移细胞的前部高不同， F-actin next to the plasma membrane also tethers the membrane and thus resists outgoing protrusions. Here， Daniel Cohen。

新生的膜凸出从MPA密度降低的区域选择性地向外延伸， 此外，。

局部低MPA密度会引导局部膜突出并在细胞迁移过程中稳定细胞极化， which was high in the front of migrating cells，MPA密度在前部低而在后部高，从后到前的MPA密度梯度是由较高的丝切蛋白介导的前部F-肌动蛋白变更，该研究于2020年6月12日发表在国际学术期刊《科学》上，用于监测膜突出和细胞迁移过程中近膜F-肌动蛋白（MPA）的密度变化， Arnold Hayer， 本期文章：《科学》：Volume 368 Issue 6496 美国斯坦福大学医学院的Tobias Meyer、Anjali Bisaria等研究人员合作发现， nascent membrane protrusions selectively extended outward from areas where MPA density was reduced. Thus，质膜旁边的F-肌动蛋白也会束缚该膜，隶属于美国科学促进会， locally low MPA density directs local membrane protrusions and stabilizes cell polarization during cell migration. DOI: 10.1126/science.aay7794 Source: https://science.sciencemag.org/content/368/6496/1205 期刊信息 Science： 《科学》， MPA density was low in the front and high in the back. Back-to-front MPA density gradients were controlled by higher cofilin-mediated turnover of F-actin in the front. Furthermore，从而抵抗向外的突起。